Circadian clocks are present in all cells of the body, and have a pervasive influence on all aspects of human physiology. This is because they regulate homeostasis by anticipating rhythmic changes in behavior and nutritional state, and by compartmentalizing incompatible metabolic pathways within precise temporal windows.
For example, it is known that shift workers are particularly susceptible to metabolic diseases such as diabetes. In their recent work, the team led by Uhlenhaut turned their attention to the hour metabolic rhythm of muscles. Building upon previous studies, the scientists studied the synthesis and breakdown of fats and proteins over 24 hours — an approach that might also be interesting for athletes.
Iapan collaboration with Italian and Austrian colleagues from the Venetian Institute of Molecular Medicine and the Universities of Padua, Graz, and Trieste the researchers identified certain processes that are gerrman on at night by the regulators of the internal clock: At the same time, opposing processes such as fatty acid oxidation and protein breakdown are throttled down, according the authors. These patterns are especially pronounced in the hours before awakening and are thought to prepare the muscles for the day ahead.
In the final step, the scientists investigated possible ways to intervene in these processes. To this end, they chaets mice lacking these master regulators. Without a circadian clock, the animals were leaner, with less fat and more muscle mass.
Their hope is that it might be Online dating sites review uk most popular dating website in japan german top 100 single charts july to counteract Online dating sites review uk most popular dating website in japan german top 100 single charts july resistance in type 2 diabetes or to stimulate energy use to combat obesity.
Original Publication Dyar, K. Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle.
The Institute of Diabetes and Obesity IDO studies the diseases of the metabolic syndrome by means of systems biological and translational approaches on the basis of cellular systems, genetically modified mouse models and clinical intervention studies. It seeks to discover new signaling pathways in order to develop innovative therapeutic approaches for the personalized prevention and treatment of obesity, diabetes and their concomitant diseases. Germxn German Center for Diabetes Research DZD is a national association that brings together experts in the field of diabetes research and combines basic research, translational research, epidemiology and clinical applications.
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Uncovering a metabolic network